Medication-assisted treatment (MAT) pairs FDA-approved medications with counseling and therapy to address opioid and alcohol addiction, tackling both the physical and mental sides of recovery. It works by stabilizing brain chemistry, cutting cravings, and stopping withdrawal symptoms before they derail recovery.

MAT uses three main FDA-approved medications: buprenorphine, methadone, and naltrexone. Each medication works differently depending on the substance and the severity of withdrawal. Buprenorphine and methadone help manage opioid withdrawal and cravings, while naltrexone blocks the effects of both opioids and alcohol. These medications stabilize brain chemistry disrupted by substance use, allowing individuals to focus on therapy and rebuilding their lives without constant physical discomfort.

New Jersey has expanded MAT programs across several counties, including Bergen, Camden, Hudson, and Middlesex, with dedicated state funding. Drug court participants receiving MAT achieved 91% treatment completion rates compared to 50% for those receiving other treatments.

How Medication Assisted Treatment Works for Recovery

MAT uses FDA-approved medications to restore balance in brain systems disrupted by substance use. These medications target the brain’s opioid receptors and neurotransmitter pathways, easing the physical symptoms that make recovery so hard. Paired with counseling and therapy, MAT addresses both the biological and psychological sides of addiction.

  • Brain Chemistry Normalization: Medications like buprenorphine and methadone bind to opioid receptors without causing euphoria. They prevent withdrawal symptoms and give the brain time to heal from chronic substance use.
  • Craving Reduction: By occupying receptor sites, MAT medications reduce intense cravings that often trigger relapse—giving clients room to focus on therapy and daily life.
  • Relapse Prevention: Medications keep brain chemistry stable during high-risk moments—even when stress or triggers hit hard.

According to the American Medical Association, overdose deaths declined from over 110,000 in 2023 to approximately 75,000 in 2024, a period when buprenorphine prescriptions increased 83% over the past decade.

Benefits of Medication Assisted Treatment for Addiction Recovery

MAT produces real, measurable results—especially for opioid and alcohol addiction. In 2023, approximately 2.3 million Americans received MAT for opioids, but NIDA reports that’s only 18% of people with opioid use disorder.

Medications stabilize brain chemistry throughout withdrawal—when symptoms are most intense. Buprenorphine and methadone act on the same brain receptors affected by opioids—preventing withdrawal without causing euphoria. This stabilization lets clients focus on therapy instead of fighting constant physical discomfort.

Without proper supervision, withdrawal from opioids or alcohol can cause dangerous medical complications. Medical supervision during medication treatment reduces risks like seizures, severe dehydration, and cardiovascular stress.

Medications dial down cravings by normalizing disrupted brain chemistry. Naltrexone blocks opioid receptors, preventing the rewarding effects of substance use. Buprenorphine partially activates these receptors, satisfying cravings without producing intoxication.

This neurological stabilization gives clients the bandwidth to engage in real therapeutic work. When cravings decrease, clients can participate more fully in individual therapy, group sessions, and skill-building activities.

According to CDC research, medications for opioid use disorder substantially reduce overdose-related and overall mortality.

Conditions Commonly Treated with Medication Assisted Treatment

MAT isn’t just for opioid addiction—it treats multiple substance use disorders. New Jersey programs treat alcohol dependence, opioid addiction, and other substance use conditions using FDA-approved medications paired with behavioral therapy.

Opioid Use Disorder

MAT is the most effective approach for treating opioid addiction—whether it’s prescription painkillers, heroin, or synthetic opioids like fentanyl. Medications like buprenorphine, methadone, and naltrexone stabilize brain chemistry while reducing cravings and blocking euphoria. New Jersey has expanded MAT access significantly, with state-funded programs in 10 counties producing measurable improvements in treatment completion and relapse rates.

Alcohol Use Disorder

FDA-approved medications for alcohol use disorder include naltrexone, acamprosate, and disulfiram. Each works through different mechanisms:

  • Naltrexone: Diminishes the pleasurable sensations associated with drinking
  • Acamprosate: Helps restore brain chemistry balance disrupted by chronic alcohol use
  • Disulfiram: Produces uncomfortable physical reactions when alcohol is consumed

Treatment pairs these medications with behavioral therapies, tackling both physical dependence and psychological patterns.

Medications Used in Medication Assisted Treatment Programs

Three FDA-approved medications anchor MAT in New Jersey: buprenorphine, naltrexone, and methadone.

Medication How It Works Administration
Buprenorphine Partial opioid agonist; reduces cravings without full euphoric effects Sublingual tablets, films, or long-acting injections
Naltrexone Opioid antagonist; blocks opioid receptors completely Daily oral tablet or monthly injection (Vivitrol)
Methadone Full opioid agonist; prevents withdrawal for 24-36 hours Daily dosing at specialized clinics

Buprenorphine latches onto opioid receptors without triggering full opioid effects. It reduces cravings and withdrawal while blocking other opioids from activating the same receptors. It carries a lower overdose risk due to its “ceiling effect,” where higher doses do not produce increased effects. Treatment programs often use buprenorphine in outpatient settings because clients can keep working and handling family responsibilities.

Naltrexone completely blocks opioid receptors, stopping opioids from producing any euphoric effects. It works for both opioid and alcohol use disorders by reducing cravings and dulling the rewarding sensations tied to substance use. The injectable form (Vivitrol) improves adherence—clients get one shot per month instead of daily pills.

Methadone stops withdrawal symptoms and reduces cravings for 24 to 36 hours per dose. Federal regulations require methadone to be dispensed through specialized Opioid Treatment Programs rather than standard pharmacies. The structured clinic setting offers built-in support through counseling and ongoing medical monitoring.

Evidence-Based Therapies Paired with Medication Assisted Treatment

MAT works best when paired with behavioral therapies that address the psychological side of addiction. Research shows that combining medications with counseling produces better outcomes than either approach alone.

CBT helps clients spot thought patterns that lead to substance use—and build healthier responses to triggers. Therapists work with clients to pinpoint high-risk situations and map out concrete plans for managing those moments. Cognitive Behavioral Therapy works well with MAT because medications handle physical cravings while therapy tackles behavioral and cognitive patterns.

Dialectical Behavior Therapy builds four core skills: mindfulness, distress tolerance, emotion regulation, and interpersonal effectiveness. These skills help clients manage intense emotions without turning to substances—especially during early recovery when medication is stabilizing physical symptoms.

Individual counseling offers personalized attention tailored to each client’s circumstances and recovery goals. Group therapy provides peer support and shared insights that strengthen individual progress. Together, they give clients the clinical attention and social support needed for long-term recovery.

Family therapy tackles relationship patterns and communication breakdowns that typically show up alongside substance use disorders. Sessions help family members see addiction as a medical condition—and learn how to support recovery without enabling destructive behaviors.

Levels of Care That Include Medication Assisted Treatment

MAT fits into multiple levels of outpatient care, so clients can receive FDA-approved medications and therapy at the intensity their recovery requires. The addiction rehab programs available through outpatient settings address both physical aspects of addiction through medications and psychological components through structured therapeutic interventions.

PHPs offer the most intensive outpatient care—MAT with close medical supervision five to seven days per week. Clients attend structured programming for several hours each day—getting medication management, individual therapy, and group sessions—then return home each evening.

IOPs offer MAT three to five days per week—a step down for clients who’ve completed PHP or need structured support while working. Sessions run mornings, afternoons, or evenings—so clients can work or attend school the same day.

Outpatient services provide MAT for long-term maintenance—usually one to two therapy sessions per week and monthly medication check-ins. This level works for clients who’ve shown stability and can live independently while getting ongoing clinical support.

Why Choose Pegasus for Medication Assisted Treatment in New Jersey

Pegasus Treatment Center delivers medication-assisted treatment in a 120-bed facility built for comfort, privacy, and high-quality clinical care. The center pairs FDA-approved medications with proven therapies like Cognitive Behavioral Therapy, Dialectical Behavioral Therapy, and trauma-informed care.

Medical supervision at Pegasus tackles withdrawal symptoms, reduces cravings, and stabilizes brain chemistry—while clients work with licensed therapists and psychiatrists. The facility includes a full gym, spa, movie theater, basketball court, and private spaces designed to support healing in comfort.

Pegasus offers flexible programming—from Partial Hospitalization and Intensive Outpatient to standard outpatient services. Clients get individualized treatment plans that integrate MAT with therapy—addressing both substance use and co-occurring mental health conditions. The center’s approach aligns with New Jersey’s statewide efforts to remove barriers to medications for opioid use disorder, contributing to improved access across all 21 counties through the continuum of care.

Insurance and Admissions for Medication Assisted Treatment Services

New Jersey has expanded insurance coverage for MAT in recent years. According to JAMA Network Open, facilities offering all three FDA-approved medications were more likely to accept Medicaid (86.7%) and Medicare (65.8%) compared to facilities with limited medication options.

The admissions process at Pegasus starts with a confidential assessment by licensed clinicians. The team reviews medical history, substance use patterns, and insurance benefits—then builds a personalized treatment plan. Admissions specialists verify insurance, coordinate with providers, and walk clients through coverage details before treatment starts.

Pegasus accepts most insurance plans—including out-of-network benefits. The admissions team works directly with insurance companies to get clients the most coverage and lowest out-of-pocket costs. Payment options go beyond traditional insurance—clients can ask about alternative arrangements during the initial consultation.

Start Your Medication Assisted Treatment Journey
in New Jersey Today

Recovery is possible with the right support and medical care. Pegasus Treatment Center provides medication assisted treatment in New Jersey—combining high-quality clinical care with compassionate, personalized attention.

Admissions starts with a confidential assessment where licensed clinicians review medical history, substance use patterns, and treatment goals. Insurance specialists work directly with clients to figure out coverage options and out-of-network benefits.

Contact Pegasus Treatment Center to speak with an admissions specialist about starting medication assisted treatment in New Jersey.

Frequently Asked Questions (FAQs)

FDA-approved MAT medications are safe when prescribed and monitored by medical professionals. Doctors regularly evaluate and adjust these medications based on how each client responds and progresses.

Treatment length varies depending on individual needs and how recovery progresses. Some people use MAT for several months; others stay on it for years as part of long-term maintenance.

MAT medications stabilize brain chemistry without causing euphoria. Physical dependence on prescribed medications under medical supervision is different from addiction—which means compulsive use despite harmful consequences.

Most insurance plans cover MAT services—medications, counseling, and medical monitoring included. New Jersey has expanded access policies since 2017, improving coverage availability across Medicaid, Medicare, and private insurance.

MAT allows people to maintain employment, family responsibilities, and daily activities. Medications stabilize withdrawal symptoms and cravings, enabling focus on work and personal obligations throughout recovery.

Contact your medical provider immediately if you miss a scheduled dose. Medical teams provide specific guidance based on medication type, dosage timing, and individual treatment plan.

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